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View Full Article BACKGROUND: We have previously reported that LES-EST has improved in outcomes in patients with GERD at 3 year follow-up (Surg Endosc. AIM: The aim of this open-label human pilot trial registry was to study the safety and efficacy of LES-EST in the cohort of GERD patients over longer 5-year follow-up. METHODS: GERD patients at least partially responsive to proton pump inhibitors (PPI) and had off-PPI GERD HRQL50% of days with PPI use).There were no unanticipated device- or stimulation-related adverse events, or untoward sensation reported between 3 and 4 year follow-up.
Electrical stimulation was delivered at 5m A, 220u Sec pulse in 12, 30 minute sessions daily.
A total of 86% of patients received an upper endoscopy in the past, but only 8% had a prior p H-metry and 2% manometry. CONCLUSION: Inadequate control of symptoms is common in GERD patients prescribed PPI therapy, and is often overlooked in daily practice. AIM: The aim of this study is to evaluate the effect of EST on postprandial reflux mechanisms, especially on transient LES relaxations (TLESRs).
These patients with insufficient symptom control should be methodically identified and considered for further diagnostics and/or treatment modification, for example with a screening questionnaire. METHODS: We studied 10 chronic GERD patients with abnormal acid exposure (p H Gastroenterology, Volume 150, Issue 4, S476.
CONCLUSION: Preliminary results on patients with LSG and GERD with bothersome symptoms despite maximal medical therapy, treated with LES electrical stimulation, revealed that LES stimulation is safe and results in a significant improvement in GERD symptoms and esophageal acid exposure.
Most patients were off their PPI therapy with remaining taking PPI at a reduced dose.
At their last follow-up (median=12 months), 75% (6/8) were off-PPIs and one each was using PPIs on 40% improvement in distal esophageal acid exposure.